Kreftkirurgi

Lindrende og palliativ kirurgi

Denne delen av vår forskningsgruppe forbedrer livene til pasienter med avansert kreft. Vi utforsker nye kirurgiske metoder for å lindre symptomer og øke pasientens komfort. Målet vårt er å etablere nye standarder for lindrende kirurgi for å optimalisere pasientresultater.

Perioperativ omsorg

Perioperativ omsorg, forberedelse og forbedret rehabilitering er nye tilnærminger innen kirurgisk onkologi som vektlegger mental og fysisk forberedelse til kirurgi. Vi utforsker individualiserte prehabiliteringsprogrammer for å forbedre pasienters fysiske og mentale helse, redusere kirurgiske komplikasjoner, og forbedre rehabilitering og langsiktige resultater.

Robotassistert kirurgi

Vår gruppe bruker robotikk for å fremme minimalt invasiv kirurgi. Vi forsker på robotassistert kirurgi for ulike kreftformer for å redusere inngrepet, forkorte sykehusopphold og forbedre pasientenes restitusjon. Ved å bruke avansert robotassistert kirurgi, har vi som mål å forbedre pasientenes livskvalitet, redusere kostnader og komplikasjoner, og redusere lengden på sykehusoppholdet.

Kirurgisk innovasjon

Innovasjon driver veksten innen kirurgisk onkologi. Vi fremmer innovativ tenkning og samarbeider med ingeniører, statistikere og andre fagpersoner for å utvikle nye kirurgiske verktøy, prosedyrer og tilnærminger. Vi ønsker å bedre kirurgisk onkologi.

Tumorbiologi 

Valg innen onkologi krever en solid forståelse av tumorbiologi. Vår forskningsgruppe undersøker de molekylære årsakene til ulike kreftformer og analyserer store epidemiologiske data for å finne mønstre og trender. Vi streber etter å informere om forebygging, påvisning og behandling av kreft.

• Augestad KM, Skyrud K, Lindahl AK, Helgeland J. Hospital and ICU Characteristics Association with Failure to Rescue. A Nationwide Longitudinal Survey. BMJ Open November 2023.
• EuroSurg Collaborative, (Augestad KM). Safety and efficacy of intraperitoneal drain placement after emergency colorectal surgery: An international, prospective cohort study.Colorectal Dis. 2023 Oct;25(10):2043-2053.
• Riis RN, Riis M, Saltyte Benth J, Augestad KM. Beyond the TaTME moratorium. Local and Distant Recurrence among Patients Operated for Low Rectal Cancers. A Five-Year Follow-up Survey from a Norwegian University Hospital. Br J Surg. 2023 Oct 10;110(11):1547-1548.
• Gravdahl E, Steine S, Augestad KM, Fredheim OM. Use and safety of peripherally inserted central catheters and midline catheters in palliative care cancer patients: a retrospective review. Support Care Cancer. 2023 Sep 19;31(10):580.
• Schultz J, Augestad KM, Saltyte-Benth J. Surgical Site Infections. Does one glove fit all? The Lancet 2023 May 6;401(10387):1496.
• NIHR Global Health Unit on Global Surgery; COVIDSurg Collaborative (Augestad KM). Elective surgery system strengthening, development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries. The Lancet. 2022 Nov 5;400(10363):1607-1617.
• Skyrud K, Lindahl AK, Helgeland J, Augestad KM. Abdominal surgical trajectories associated with failure to rescue. Int J Qual Health Care. 2022 Nov 17;34(4).
• Banipal GS, Stimec BV, Andersen SN, Faerden AE, Edwin B, Baral J, Nesgaard JM, Benth JŠ, Ignjatovic D; R. C. C. study group (Augestad KM). Comparing 5-Year Survival Rates Before and After Re-stratification of Stage I-III Right-Sided Colon Cancer Patients by Establishing the Presence/Absence of Occult Tumor Cells and Lymph Node Metastases in the Different Levels of Surgical Dissection. J Gastrointest Surg. 2022 Oct;26(10):2201-2211.
• EuroSurg Collaborative (Augestad KM). Intraperitoneal drain placement and outcomes after elective colorectal surgery: international matched, prospective, cohort study. Br J Surg. 2022 Mar 30.
• COVIDSurg Collaborative (Augestad KM). Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study. Lancet Oncol. 2021 Nov;22(11):1507-1517.
• COVIDSurg Collaborative (Augestad KM). Global wealth disparities drive adherence to COVID-safe pathways in head and neck cancer surgery. BJS Open. 2021 Nov 9;5(6)
• Helgeland J, Skyrud K, Lindahl AK, Keller D, Augestad KM. Benchmarking of abdominal surgery: a study evaluating the HARM score in a European national cohort. BJS Open. 2020 Apr 21;4(4):637-44.
• COVIDSurg Collaborative (Augestad KM). Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study. J Clin Oncol. 2021 Jan 1;39(1):66-78.
• COVIDSurg Collaborative (Augestad KM). Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study. J Clin Oncol. 2021 Jan 1;39(1):66-78.
• Syltern J, Jørgensen G, Norstein J, Augestad KM. Fracture and embolization of an implantable venous access device in patient with atrial septal defect. J Surg Case Rep. 2020 Dec 31;2020(12).
• de Paul TR, Augestad KM, Kiran RP, Keller DS. Management of the positive pathologic circumferential resection margin in rectal cancer: A national cancer database (NCDB) study. Eur J Surg Oncol. 2020 Aug 1: S0748-7983(20)30660-0.
• EuroSurg Collaborative (Augestad KM). Management of COMPlicAted intra-abdominal collectionS after colorectal Surgery (COMPASS): protocol for a multicentre, observational, prospective international study of drain placement practices in colorectal surgery. Colorectal Dis. 2020 Jul 27. doi: 10.1111/codi.15275.
• COVIDSurg Collaborative (Augestad KM). Elective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans. Br J Surg. 2020 May
• GlobalSurg Collaborative (Augestad et al). Global variation in anastomosis and end colostomy formation following left-sided colorectal resection. BJS Open. 2019 Feb 28;3(3):403-414.
• Augestad KM, Keller DS, Bakaki PM, Rose J, Koroukian SM, Øresland T, Delaney CP. The impact of rectal cancer tumor height on recurrence rates and metastatic location: A competing risk analysis of a national database. Cancer Epidemiol. 2018 Apr; 53:56-64. doi: 10.1016/j.canep.2018.01.009. Epub 2018 Feb 4. PMID: 29414633
• Brady J, Bona K, Hohman SF, Crawshaw B, Leinicke JA, Steele SR, Augestad KM, Delaney CP. Application of a Simple, Affordable Quality Metric Tool to Colorectal, Upper Gastrointestinal, Hernia and Hepatobiliary Surgery Patients: The HARM Score. Surg Endosc 2017 Dec 27.
• Augestad KM, Merok MA, Ignatovic D. Tailored Treatment of Colorectal Surgery. Anatomical, Surgical and Genetic Considerations. Invited Review. Clinical Medicine Insights. Oncology 2017.
• Crawshaw BP, Keller DS, Brady JT, Augestad KM, Schiltz NK, Chandra Pillai AL, Koroukian SM, Navale SM, Steele SR, Delaney C. Validation of the HARM scores, a reliable and simple tool to measure quality and outcomes in gastrointestinal surgery.  American Journal of Surgery 2017.
• Stimec B, Andersen BT, Benz SR, Fasel JH, Augestad KM, Ignjatovic D. Retromesenteric course of the middle colic artery. Challenges and pitfalls in D3 right colectomy for cancer. Sugical Endoscopy 2017.
• Augestad KM, Rose J, Bakaki P, Kirokian S, Delaney CP. Metastatic spread pattern after curative colorectal cancer surgery. A retrospective, longitudinal analysis. Cancer Epidemiology 2015 Aug 12: 1877-7821(15)00161-7.
• Crawshaw B, Chien H, Augestad KM, Delaney CP. Impact of minimally invasive surgery on healthcare utilization and cost in patients undergoing colorectal procedures. JAMA Surgery. 2015 May;150(5):410-5.
• Crawshaw B, Augestad KM, Keller, Swendsiad B, Nobel T, Champagne B, Stein S, Delaney CP, Reynolds H. Multivisceral resections for advanced rectal cancer. Outcomes and experience at a single institution. American Journal of Surgery. 2014 Dec 17.
• Park, K, Keller D, Augestad KM, Delaney CP. Integration of Open and Laparoscopic Approaches for Rectal Cancer Resections. Surgical Endoscoscopy. 2014 Jul;28(7):2129-36.
• Augestad KM, Norum J, Rose J, Lindsetmo RO. A Prospective Analysis of False Positive Events in a National Colon Cancer Surveillance Program. BMC Health Services Research. 2014 Mar 27;14:137.
• KM, Lindsetmo RO, Norum J, Vonen B et al. Cost-effectiveness and quality of life in general practitioner versus surgeon-organised follow-up after curative colon cancer resection. A randomized controlled trial. BMJ Open. 2013: 3(4).
• Augestad Knut M, Lindsetmo Rolv-Ole, Stulberg Jonah, Senagore Anthony, Champagne Brad, Heriot Alexander G, Leblanc Fabien, Reynolds Harry, Delaney Conor P, International Rectal Cancer Study Group. International trends of operative treatment of rectal cancer. American Journal Surgery. 2011 Mar; 2011(3): 353-7; discussion 357-8.
• Augestad KM, Leblanc F, Delaney CP. Role of pharmacologic treatment of postoperative ileus. Seminars in Colon & Rectal Surgery. Volume 21, Issue 3. September 2010; 153-159.
• Leblanc F, Champagne BJ, Augestad KM, Stein SL, Mardenstein E, Reynolds HL Jr, Delaney CP. Single incision laparoscopic colectomy: technical aspects, feasibility and expected benefits. Diagnostic Therapy and Endoscopy. 2010; 2010:913216.
• Augestad KM, Delaney CP. Postoperative ileus. Impact of pharmacological treatment, laparoscopic surgery and enhanced recovery pathways. Invited Editorial. World Journal Gastroenterol 2010; 16(17): 2067-2074.
• Augestad KM, Lindsetmo Rolv-Ole, Stulberg Jonah, Senagore Anthony, Champagne Brad, Heriot Alexander G, Leblanc Fabien, Reynolds Harry, Delaney Conor P, International Rectal Cancer Study Group. International preoperative rectal cancer management: staging, neoadjuvant treatment and impact of multidisciplinary teams. World Journal Surgery. 2010; 34(11): 2689-700.
• Augestad KM, Vonen B, Aspevik R, Nestvold T, Ringberg U, Johnsen R, Norum J, Lindsetmo RO. Should the surgeon or the general practitioner (GP) follow up patients after surgery for colon cancer? A randomized controlled trial protocol focusing on quality of life, cost-effectiveness and serious clinical events. BMC Health Services Research. 2008 Jun 25; 8:137.

Pasientsentrert behandling av endetarmskreft ved hjelp av tumoroider - PROGRESS studien

• avdeling for kolorektalkirurgi, Columbia University, New York (columbiasurgery.org)
• Oncosyne Laboratories (oncosyne.no)
• avdeling for kirurgi Ullevål, Oslo universitetssykehus, Oslo, Norge
• avdeling for kirurgi Haukeland universitetssykehus, Helse Bergen, Bergen, Norge
• avdeling for kirurgi, Groningen universitetssykehus, Nederland
• Norsk Gastrointestinal Cancer Gruppe (ngicg.no)
• avdeling for kirurgi, Aarhus Universitetssykehus, Aarhus, Danmark
• avdeling for kirurgi, Nordlandssykehuset, Bodø, Norge
• Surgical Artificial Intelligence Research Academy, Toronto, Canada (temertysimcentre.com)
• forskningsgruppe for klinisk effektivitet, Universitetet i Oslo (med.uio.no)